Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

α-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson’s disease patients

23 Feb 2017

Abstract excerpt

Parkinson's disease (PD) is characterized by the presence of inclusions known as Lewy bodies, which mainly consist of α-synuclein (α-syn) aggregates. There is growing evidence that α-syn self-propagates in non-neuronal cells, thereby contributing to the progression and spread of PD pathology in the brain. Tunneling nanotubes (TNTs) are long, thin, F-actin-based membranous channels that connect cells and have been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neurological disorders and treatments
Share to Neuroscience and Neuropharmacology Research
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28230073
DOI: 10.1038/srep42984

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

α-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson’s disease patientsPMID 28230073Read ↗

Potential Modes of Intercellular α-Synuclein TransmissionSemantic proximity Read ↗

Dissecting the potential molecular mechanisms underlying α-synuclein cell-to-cell transfer in Parkinson's diseaseSemantic proximity Read ↗

A deadly spread: cellular mechanisms of α-synuclein transfer.Semantic proximity Read ↗

Transfer of polyglutamine aggregates in neuronal cells occurs in tunneling nanotubesSemantic proximity Read ↗

Molecular events underlying the cell‐to‐cell transmission of α‐synucleinSemantic proximity Read ↗

An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of a-synucleinSemantic proximity Read ↗

Fate and propagation of endogenously formed Tau aggregates in neuronal cellsSemantic proximity Read ↗

Structural conversion of α-synuclein at the mitochondria induces neuronal toxicitySemantic proximity Read ↗

Cell-to-Cell Transmission of Tau and α-SynucleinSemantic proximity Read ↗

α‐Synuclein fibrils explore actin‐mediated macropinocytosis for cellular entry into model neuroblastoma neuronsSemantic proximity Read ↗

Change in the Oligomeric State of α-Synuclein Variants in Living Cells.Semantic proximity Read ↗

Glucosylceramide induced ectosomes propagate pathogenic α-synuclein in Parkinson’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.