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Article

Genomics-driven reconstruction of acinetobacter NAD metabolism: insights for antibacterial target selection.

The Journal of biological chemistry - 10 Dec 2010

Sorci Leonardo, Blaby Ian, De Ingeniis Jessica, Gerdes Svetlana, Raffaelli Nadia, de Crécy Lagard Valérie, Osterman Andrei

Abstract excerpt

Enzymes involved in the last steps of NAD biogenesis, nicotinate mononucleotide adenylyltransferase (NadD) and NAD synthetase (NadE), are conserved and essential in most bacterial species and are established targets for antibacterial drug development. Our genomics-based reconstruction of NAD metabolism in the emerging pathogen Acinetobacter baumannii revealed unique features suggesting an alternative targeting...

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Identifiers

PMID: 20926389
DOI: 10.1074/jbc.M110.185629
PMCID: PMC2998121

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