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NAD+ Degrading Enzymes, Evidence for Roles During Infection

16 Aug 2021

Abstract excerpt

Declines in cellular nicotinamide adenine dinucleotide (NAD) contribute to metabolic dysfunction, increase susceptibility to disease, and occur as a result of pathogenic infection. The enzymatic cleavage of NAD+transfers ADP-ribose (ADPr) to substrate proteins generating mono-ADP-ribose (MAR), poly-ADP-ribose (PAR) or O-acetyl-ADP-ribose (OAADPr). These important post-translational modifications have roles in...

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PMID: 34485381
DOI: 10.3389/fmolb.2021.697359

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