Article

Treatment of SARS-CoV-2 induced pneumonia with NAD+ in a mouse model

2020-10-30

Abstract excerpt

<title>Abstract</title> <p>The global COVID-19 epidemic has spread rapidly around the world and has already caused the death of more than one million people. As there is yet no vaccine, it is urgent to develop effective strategies to treat COVID-19 patients. Here, we used a mouse-adapted SARS-CoV-2 infection model to explore potential therapeutic targets for SARS-CoV-2 pneumonia. Global gene expression analysis o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fe32d5c8-f976-5618-ba05-c24d643e0643
DOI: 10.21203/rs.3.rs-96999/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Treatment of SARS-CoV-2 induced pneumonia with NAD+ in a mouse modelDOI 10.21203/rs.3.rs-96999/v1Read

NAD <sup>+</sup> metabolism is a key modulator of bacterial respiratory epithelial infectionsSemantic proximity Read

Metabolic reprogramming and epigenetic changes of vital organs in SARS-CoV-2–induced systemic toxicitySemantic proximity Read

Decoding NAD+ Metabolism in COVID-19: Implications for Immune Modulation and TherapySemantic proximity Read

Elucidation of the antiviral mechanism of cystine and theanine through transcriptome analysis of mice and comparison with COVID-19 gene set dataSemantic proximity Read

CNP blocks mitochondrial depolarization and inhibits SARS-CoV-2 replication <i>in vitro</i> and <i>in vivo</i>Semantic proximity Read

Low-dose cadmium potentiates lung inflammatory response to 2009 pandemic H1N1 influenza virus in miceSemantic proximity Read

ACE2 and a Traditional Chinese Medicine Formula NRICM101 Could Alleviate the Inflammation and Pathogenic Process of Acute Lung InjurySemantic proximity Read

A humanized mouse model of chronic COVID-19 to evaluate disease mechanisms and treatment optionsSemantic proximity Read

Increased Neutrophil H2O2 Production and Enhanced Pulmonary Clearance of Klebsiella pneumoniae in G6PD A- MiceSemantic proximity Read

Pyronaridine Protects Against SARS-CoV-2 in MouseSemantic proximity Read

Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent mannerSemantic proximity Read

Targeting NAD+ metabolism: dual roles in cancer treatmentSemantic proximity Read