Article

Ascitic Shear Stress Activates GPCRs and Downregulates Mucin 15 to Promote Ovarian Cancer Malignancy

2024-11-25

Abstract excerpt

<title>Abstract</title> <p>The accumulation of ascites in patients with ovarian cancer increases their risk of transcoelomic metastasis. Although common routes of peritoneal dissemination are known to follow distinct paths of circulating ascites, the mechanisms that initiate these currents and subsequent fluid shear stresses are not well understood. Here, we developed a patient-based, boundary-driven computationa...

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Literature Corpus work: 3f316b59-ed8e-5ad5-9dc1-effa0382271a
DOI: 10.21203/rs.3.rs-5160301/v2

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