Article
Gremlin 1 is required for macrophage M2 polarization
2022-12-07
Abstract excerpt
Pro-proliferative, M2-like polarization of macrophages is a critical step in the development of fibrosis and remodeling in chronic lung diseases such as pulmonary fibrosis and pulmonary hypertension. Macrophages in healthy and diseased lungs express gremlin 1 (Grem1), a secreted glycoprotein that acts in both paracrine and autocrine manners to modulate cellular function. Increased Grem1 expression plays a central...
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Identifiers and source
- Literature Corpus work
- 5f80d747-2f05-587e-9e3a-4432572139d3
- DOI
- 10.1101/2022.12.07.519468