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Temporal transcriptional response of <i>Candida glabrata</i> during macrophage infection reveals a multifaceted transcriptional regulator CgXbp1 important for macrophage response and drug resistance

2021-09-28

Abstract excerpt

Candida glabrata can thrive inside macrophages and tolerate high levels of azole antifungals. These innate abilities render infections by this human pathogen a clinical challenge. How C. glabrata reacts inside macrophages and what is the molecular basis of its drug tolerance are not well understood. Here, we mapped genome-wide RNA polymerase II (RNAPII) occupancy in C. glabrata to delineate its transcriptional r...

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Literature Corpus work
b031c71a-cf5a-5c95-9f60-6fa3974ec710
DOI
10.1101/2021.09.28.462173
Open publication

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Temporal transcriptional response of <i>Candida glabrata</i> during macrophage infection reveals a multifaceted transcriptional regulator CgXbp1 important for macrophage response and drug resistanceDOI 10.1101/2021.09.28.462173
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