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Ferroptosis-disulfidptosis-related CHMP6 is a clinico-immune target in colorectal cancer

21 Jul 2025

Abstract excerpt

BACKGROUND: Ferroptosis and disulfidptosis are newly discovered forms of regulated cell death that play critical roles in cancer progression, metabolism, and immune evasion. However, their interplay and combined influence on colorectal cancer (CRC) progression remain insufficiently understood. METHODS: We developed a ferroptosis-disulfidptosis-related gene (FDRG) score using machine-learning algorithms to analyze...

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PMID: 40691598
DOI: 10.1186/s13062-025-00676-1

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