Article

Dual blockade of adenosine A2A and A 2B receptors is required to reverse NECA-induced immunosuppression in human macrophages: Implications for cancer immunotherapy

2025-09-09

Abstract excerpt

<title>Abstract</title> Adenosine receptors are a target for cancer immunotherapy, with high levels of adenosine in the tumour microenvironment producing immunosuppressive effects. Most clinical trials in cancer are targeting the A2A adenosine receptor, but evidence suggests that both the A2A and A2B receptors are important for determining the effect of adenosine in myeloid-lin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aa2423ac-2792-5200-8f2c-4e314cad8cf4
DOI: 10.21203/rs.3.rs-6975438/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dual blockade of adenosine A2A and A 2B receptors is required to reverse NECA-induced immunosuppression in human macrophages: Implications for cancer immunotherapyDOI 10.21203/rs.3.rs-6975438/v1Read

Polarized Tissue-Derived Macrophages Display Enhanced M2d Phenotype after Prolonged Stimulation with Adenosine A2A Receptor Agonist in the Presence of LPS.Semantic proximity Read

Adenosine receptor activation promotes macrophage class switching from LPS-induced acute inflammatory M1 to anti-inflammatory M2 phenotype.Semantic proximity Read

HIF-dependent induction of adenosine receptor A2b skews human dendritic cells to a Th2-stimulating phenotype under hypoxia.Semantic proximity Read

A2A adenosine receptor protects tumors from antitumor T cells.Semantic proximity Read

Tumor-derived exosomes promote angiogenesis via adenosine A2B receptor signaling.Semantic proximity Read

Adenosine and cAMP signalling skew human dendritic cell differentiation towards a tolerogenic phenotype with defective CD8(+) T-cell priming capacity.Semantic proximity Read

The Inhibitory Effect of Adenosine on Tumor Adaptive Immunity and Intervention StrategiesSemantic proximity Read

A2A adenosine receptor agonist reduced MMP8 expression in healthy M2-like macrophages but not in macrophages from ankylosing spondylitis patientsSemantic proximity Read

Purinergic signaling during macrophage differentiation results in M2 alternative activated macrophages.Semantic proximity Read

Adenosine Receptor Signaling Targets Both PKA and Epac Pathways to Polarize Dendritic Cells to a Suppressive Phenotype.Semantic proximity Read

A1 adenosine receptor upregulation and activation attenuates neuroinflammation and demyelination in a model of multiple sclerosis.Semantic proximity Read

DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization.Semantic proximity Read