CRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti-tumoral compounds

Abstract excerpt

FOXL2 is a transcription factor essential for sex determination and ovary development and maintenance. Mutations in this gene are implicated in syndromes involving premature ovarian failure and granulosa cell tumors (GCTs). This rare cancer accounts for less than 5% of diagnosed ovarian cancers and is causally associated with the FOXL2 c.402C>G, p.C134W mutation in 97% of the adult cases (AGCTs). In this study, we...

Topics

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• Forkhead Box Protein L2
• Forkhead Transcription Factors
• Granulosa Cell Tumor
• Mutation, Missense
• Ovarian Neoplasms
• Point Mutation
• Sequence Analysis, RNA
• Taq Polymerase

Identifiers and source

Literature Corpus work

4eb64d3c-5cc5-537c-ba3d-b774704603da

DOI

10.1101/2024.07.01.601520