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Article

Itraconazole targets cell cycle heterogeneity in colorectal cancer.

The Journal of experimental medicine - 2 Jul 2018

Buczacki Simon J A, Popova Semiramis, Biggs Emma, Koukorava Chrysa, Buzzelli Jon, Vermeulen Louis, Hazelwood Lee, Francies Hayley, Garnett Mathew J, Winton Douglas J

Abstract excerpt

Cellular dormancy and heterogeneity in cell cycle length provide important explanations for treatment failure after adjuvant therapy with S-phase cytotoxics in colorectal cancer (CRC), yet the molecular control of the dormant versus cycling state remains unknown. We sought to understand the molecular features of dormant CRC cells to facilitate rationale identification of compounds to target both dormant and...

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Identifiers

PMID: 29853607
DOI: 10.1084/jem.20171385
PMCID: PMC6028508

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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