Article

B3GALT6 Promotes Dormant Breast Cancer Cell Survival and Recurrence by Enabling Heparan Sulfate-Mediated FGF Signaling

2023-02-03

Abstract excerpt

<h4>Summary</h4> Breast cancer mortality results primarily from incurable recurrent tumors seeded by dormant, therapy-refractory residual tumor cells (RTCs). Understanding the mechanisms enabling dormant RTC survival is therefore essential for improving patient outcomes. We derived a dormancy-associated RTC signature that mirrors the transcriptional response to neoadjuvant chemotherapy in patients and is enriched...

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Literature Corpus work: a0dafe67-70eb-53b1-9ba1-e8aaa5869050
DOI: 10.1101/2023.01.31.526529

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