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Article

Stable expansion of high-grade serous ovarian cancer organoids requires a low-Wnt environment.

The EMBO journal - 16 Mar 2020

Hoffmann Karen, Berger Hilmar, Kulbe Hagen, Thillainadarasan Sukanija, Mollenkopf Hans-Joachim, Zemojtel Tomasz, Taube Eliane, Darb-Esfahani Silvia, Mangler Mandy, Sehouli Jalid, Chekerov Radoslav, Braicu Elena I, Meyer Thomas F, Kessler Mirjana

Abstract excerpt

High-grade serous ovarian cancer (HGSOC) likely originates from the fallopian tube (FT) epithelium. Here, we established 15 organoid lines from HGSOC primary tumor deposits that closely match the mutational profile and phenotype of the parental tumor. We found that Wnt pathway activation leads to growth arrest of these cancer organoids. Moreover, active BMP signaling is almost always required for the generation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32009247
DOI: 10.15252/embj.2019104013
PMCID: PMC7073464

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