Article

Netrin signaling mediates survival of dormant epithelial ovarian cancer cells

2023-08-31

Abstract excerpt

Dormancy in cancer is a clinical state in which residual disease remains undetectable for a prolonged duration. At a cellular level, rare cancer cells cease proliferation and survive chemotherapy and disseminate disease. We created a suspension culture model of high grade serous ovarian cancer (HGSOC) dormancy and devised a novel CRISPR screening approach to identify survival genes in this context. In combination...

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Literature Corpus work: 347ef3a1-e678-5a8b-821c-d1b39f2a6088
DOI: 10.1101/2023.08.29.555435

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