Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The miR-181a-SFRP4 Axis Regulates Wnt Activation to Drive Stemness and Platinum Resistance in Ovarian Cancer.

Cancer research - 15 Apr 2021

Belur Nagaraj Anil, Knarr Matthew, Sekhar Sreeja, Connor R Shae, Joseph Peronne, Kovalenko Olga, Fleming Alexis, Surti Arshia, Nurmemmedov Elmar, Beltrame Luca, Marchini Sergio, Kahn Michael, DiFeo Analisa

Abstract excerpt

Wnt signaling is a major driver of stemness and chemoresistance in ovarian cancer, yet the genetic drivers that stimulate its expression remain largely unknown. Unlike other cancers, mutations in the Wnt pathway are not reported in high-grade serous ovarian cancer (HGSOC). Hence, a key challenge that must be addressed to develop effective targeted therapies is to identify nonmutational drivers of Wnt activation....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Cisplatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down-Regulation

Share to Molecular Targeted Therapy

Share to Neoplasm Grading

Share to Neoplastic Stem Cells

Share to Ovarian Neoplasms

Share to Wnt Signaling Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 33574092
DOI: 10.1158/0008-5472.CAN-20-2041
PMCID: PMC8137569

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The miR-181a-SFRP4 Axis Regulates Wnt Activation to Drive Stemness and Platinum Resistance in Ovarian Cancer.PMID 33574092Read ↗

The STAT3-miRNA-92-Wnt Signaling Pathway Regulates Spheroid Formation and Malignant Progression in Ovarian CancerSemantic proximity Read ↗

MiR-1207 overexpression promotes cancer stem cell-like traits in ovarian cancer by activating the Wnt/β-catenin signaling pathway.Semantic proximity Read ↗

Integrin-linked kinase-frizzled 7 interaction maintains cancer stem cells to drive platinum resistance in ovarian cancerSemantic proximity Read ↗

Wnt/beta-catenin signaling activates microRNA-181 expression in hepatocellular carcinomaSemantic proximity Read ↗

LGR4 Maintains HGSOC Cell Epithelial Phenotype and Stem-Like TraitsSemantic proximity Read ↗

Regulation of Ovarian Cancer Stem Cells or Tumor-Initiating CellsSemantic proximity Read ↗

Cancer associated fibroblasts serve as an ovarian cancer stem cell niche through noncanonical Wnt5a signalingSemantic proximity Read ↗

Targeting the Wnt-Regulatory Protein CTNNBIP1 by microRNA-214 Enhances the Stemness and Self-Renewal of Cancer Stem-Like Cells in Lung AdenocarcinomasSemantic proximity Read ↗

Most Commonly Mutated Genes in High-Grade Serous Ovarian Carcinoma Are Nonessential for Ovarian Surface Epithelial Stem Cell Transformation.Semantic proximity Read ↗

Pan-cancer genomic amplifications underlie a Wnt hyperactivation phenotype associated with stem cell-like features leading to poor prognosisSemantic proximity Read ↗

Epigenetic silencing of SFRP5 is related to malignant phenotype and chemoresistance of ovarian cancer through Wnt signaling pathway.Semantic proximity Read ↗

Silencing PTEN in the fallopian tube promotes enrichment of cancer stem cell-like function through loss of PAX2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.