Article

HORNET: Tools to find genes with causal evidence and their regulatory networks using eQTLs

2024-10-30

Abstract excerpt

<h4>Motivation</h4> Nearly two decades of genome-wide association studies (GWAS) have identify thousands of disease-associated genetic variants, but very few genes with evidence of causality. Recent methodological advances demonstrate that Mendelian Randomization (MR) using expression quantitative loci (eQTLs) as instrumental variables can detect potential causal genes. However, existing MR approaches are not well...

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Literature Corpus work: aa016700-981a-5778-acd6-c3db752a8adb
DOI: 10.1101/2024.10.28.24316273

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