Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular signature of SETD2 and m6A modifiers in the pathogenesis of different grades of adult-type diffuse gliomas.

Molecular biology reports - 16 Apr 2026

Kumari Subhadra, M Kirthik Roshan, Pal Rituparna, Jaiswal Sushila, Jaiswal Awadhesh, Kumar Santosh, Muthuswamy Srinivasan

Abstract excerpt

Gliomas are the most common primary brain tumours with considerable heterogeneity and aggressive clinical behaviour. The recent WHO 2021 classification emphasises molecular markers, such as IDH1/2 mutations and 1p/19q codeletion, for refined diagnosis and prognosis. Among emerging regulatory mechanisms, RNA N6-methyladenosine (m6A) modifications and their interplay with SETD2 have attracted attention for their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine
Share to Brain Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glioma

Share to Histone-Lysine N-Methyltransferase

Share to Methyltransferases

Share to Neoplasm Grading

Share to RNA-Binding Proteins

Share to RNA Splicing Factors

Source

Identifiers

PMID: 41989662
DOI: 10.1007/s11033-026-11767-1

Genes

SETD2
ALKBH5
METTL3
WTAP
YTHDF1
YTHDF2
FTO
IDH1
METTL14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular signature of SETD2 and m6A modifiers in the pathogenesis of different grades of adult-type diffuse gliomas.PMID 41989662Read ↗

IDH1-dependent m6A methylation defines transcriptomic heterogeneity in gliomaSemantic proximity Read ↗

Deregulating m6A regulators leads to altered RNA biology in glioma cell linesSemantic proximity Read ↗

miRNAs and related genetic biomarkers according to the WHO glioma classification: From diagnosis to future therapeutic targetsSemantic proximity Read ↗

DNA methylation signatures for 2016 WHO classification subtypes of diffuse gliomasSemantic proximity Read ↗

Identification of N6-Methyladenosine-Related Gene Based Prognostic Signature to Predict Survival and Potential Therapeutic Drugs in GliomaSemantic proximity Read ↗

Distinct molecular profile of diffuse cerebellar gliomas.Semantic proximity Read ↗

m6A function and tumor microenvironment infiltration characteristics in gliomaSemantic proximity Read ↗

Integrated transcriptomic analysis reveals KRAS-associated gene activation and epigenetic regulation in mutant IDH1 glioma.Semantic proximity Read ↗

RNA N6-Methyladenosine (m6A) regulates the cell cycle in Diffuse Midline Glioma (DMG) and confers sensitivity to FTO inhibitionSemantic proximity Read ↗

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.Semantic proximity Read ↗

Proteomics separates adult-type diffuse high-grade gliomas in metabolic subgroups independent of 1p/19q codeletion and across IDH mutational status.Semantic proximity Read ↗

Canonical amplifications and CDKN2A/B loss refine IDH1/2-mutant astrocytoma prognosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.