Article
Characterization of tumor evolution by functional clonality and phylogenetics in hepatocellular carcinoma.
Communications biology - 29 Mar 2024
Kacar Zeynep, Slud Eric, Levy Doron, Candia Julián, Budhu Anuradha, Forgues Marshonna, Wu Xiaolin, Raziuddin Arati, Tran Bao, Shetty Jyoti, Pomyen Yotsawat, Chaisaingmongkol Jittiporn, Rabibhadana Siritida, Pupacdi Benjarath, Bhudhisawasdi Vajarabhongsa, Lertprasertsuke Nirush, Auewarakul Chirayu, Sangrajrang Suleeporn, Mahidol Chulabhorn, Ruchirawat Mathuros, Wang Xin Wei
Abstract excerpt
Hepatocellular carcinoma (HCC) is a molecularly heterogeneous solid malignancy, and its fitness may be shaped by how its tumor cells evolve. However, ability to monitor tumor cell evolution is hampered by the presence of numerous passenger mutations that do not provide any biological consequences. Here we develop a strategy to determine the tumor clonality of three independent HCC cohorts of 524 patients with...
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