Article

SFPQ intron retention, reduced expression and aggregate formation in central nervous system tissue are pathological features of amyotrophic lateral sclerosis

2020-09-23

Abstract excerpt

<h4>Background</h4> Splicing factor proline and glutamine rich (SFPQ, also known as polypyrimidine tract-binding protein-associated-splicing factor, PSF) is a RNA-DNA binding protein with roles in key cellular pathways such as DNA transcription and repair, RNA processing and paraspeckle formation. Dysregulation of SFPQ is emerging as a common pathological feature of multiple neurodegenerative diseases including a...

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Literature Corpus work: a9bfe0f4-2cc0-544b-a1a2-d99d366c980b
DOI: 10.1101/2020.09.22.309062

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