Article

Familial ALS-associated <i>SFPQ</i> variants promote the formation of SFPQ cytoplasmic aggregates that reduce surface AMPA receptor expression in primary neurons

2022-03-12

Abstract excerpt

<h4>ABSTRACT</h4> SFPQ is a nuclear RNA-binding protein that is involved in a wide range of physiological processes including neuronal development and homeostasis. However, the mislocalization and cytoplasmic aggregation of SFPQ are associated with the pathophysiology of amyotrophic lateral sclerosis (ALS). We have previously reported that zinc mediates SFPQ polymerization and promotes the formation of cytoplasmi...

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Literature Corpus work: 16219ee5-f5e2-5809-a6ad-69ec593b5d41
DOI: 10.1101/2022.03.10.483757

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