Article

SFPQ dysregulation promotes TDP-43 pathology through a pathogenic feedback loop

2026-07-25

Abstract excerpt

TDP-43 proteinopathies comprise a group of clinically distinct neurodegenerative disorders unified by common pathological changes in the RNA-binding protein TDP-43, including nuclear loss of function (LOF), cytoplasmic mislocalisation and aggregation. The presence of these hallmarks across diverse diseases, such as frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), alzheimer’s disease (AD) and Lim...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a3f6e110-b5c2-5777-844f-836b7b9445b8
DOI: 10.64898/2026.07.22.740184

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SFPQ dysregulation promotes TDP-43 pathology through a pathogenic feedback loopDOI 10.64898/2026.07.22.740184Read

Mechanisms of TDP-43 Proteinopathy Onset and Propagation.Semantic proximity Read

Decoding TDP-43: the molecular chameleon of neurodegenerative diseasesSemantic proximity Read

Understanding age-related pathologic changes in TDP-43 functions and the consequence on RNA splicing and signalling in health and diseaseSemantic proximity Read

Connecting RNA-Modifying Similarities of TDP-43, FUS, and SOD1 with MicroRNA Dysregulation Amidst A Renewed Network Perspective of Amyotrophic Lateral Sclerosis Proteinopathy.Semantic proximity Read

A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicitySemantic proximity Read

An ALS-associated TARDBP mutation drives cryptic exon inclusion and RNA dysregulationSemantic proximity Read

Biology and Pathobiology of TDP-43 and Emergent Therapeutic Strategies.Semantic proximity Read

An aberrant cytoplasmic intron retention programme is a blueprint for ALS-related RBP mislocalizationSemantic proximity Read

Stress granule mediated protein aggregation and underlying gene defects in the FTD-ALS spectrumSemantic proximity Read

SFPQ intron retention, reduced expression and aggregate formation in central nervous system tissue are pathological features of amyotrophic lateral sclerosisSemantic proximity Read

RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathySemantic proximity Read

TDP-43 aggregation mirrors TDP-43 knockdown, affecting the expression levels of a common set of proteinsSemantic proximity Read