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Article

Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates in primary neurons.

Open biology - 1 Sept 2022

Widagdo Jocelyn, Udagedara Saumya, Bhembre Nishita, Tan Jing Zhi Anson, Neureiter Lara, Huang Jie, Anggono Victor, Lee Mihwa

Abstract excerpt

Splicing factor proline- and glutamine-rich (SFPQ) is a nuclear RNA-binding protein that is involved in a wide range of physiological processes including neuronal development and homeostasis. However, the mislocalization and cytoplasmic aggregation of SFPQ are associated with the pathophysiology of amyotrophic lateral sclerosis (ALS). We have previously reported that zinc mediates SFPQ polymerization and promotes...

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Source

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Identifiers

PMID: 36168806
DOI: 10.1098/rsob.220187
PMCID: PMC9516340

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates in primary neurons.PMID 36168806Read ↗

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