Article

An aberrant cytoplasmic intron retention programme is a blueprint for ALS-related RBP mislocalization

2020-07-21

Abstract excerpt

<h4>SUMMARY</h4> We recently described aberrant cytoplasmic SFPQ intron-retaining transcripts (IRTs) and concurrent SFPQ protein mislocalization as a new hallmark of amyotrophic lateral sclerosis (ALS). However the generalizability and potential roles of cytoplasmic IRTs in health and disease remain unclear. Here, using time-resolved deep-sequencing of nuclear and cytoplasmic fractions of hiPSCs undergoing motor...

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Literature Corpus work: 5715f2e9-da45-5237-9aa7-473977e6627e
DOI: 10.1101/2020.07.20.211557

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