Article

A Dirichlet-multinomial mixed model for detecting differential abundance of mutational signatures

2024-08-06

Abstract excerpt

<title>Abstract</title> <p>Mutational processes of diverse origin leave their imprints in the genome during tumour evolution. These imprints are called mutational signatures and they have been characterised for point mutations, structural variants and copy number changes. Each signature has an exposure, or abundance, per sample, which indicates how much a process has contributed to the overall genomic change. Mut...

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Literature Corpus work: b3c62589-57ad-50ed-a529-4847bebcdac4
DOI: 10.21203/rs.3.rs-4700438/v1

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