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Cysteine reactivity profiling identifies host regulators of <i>Mycobacterium tuberculosis</i> replication in human macrophages

2025-09-03

Abstract excerpt

Innate immune cells such as monocytes and macrophages provide the earliest defense against infection by intracellular pathogens by initiating signaling pathways and restricting pathogen replication. However, the full complement of proteins that mediate cell-autonomous immunity remains incompletely defined. Here, we applied cysteine-directed activity-based protein profiling (ABPP) to map proteome-wide cysteine reac...

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Identifiers and source

Literature Corpus work
cccd0e82-6c32-56f9-a900-718a0c6d15ef
DOI
10.1101/2025.08.30.673236
Open publication

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Cysteine reactivity profiling identifies host regulators of <i>Mycobacterium tuberculosis</i> replication in human macrophagesDOI 10.1101/2025.08.30.673236
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