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Antibacterial Activity of and Resistance to Small Molecule Inhibitors of the ClpP Peptidase

18 Sept 2013

Abstract excerpt

There is rapidly mounting evidence that intracellular proteases in bacteria are compelling targets for antibacterial drugs. Multiple reports suggest that the human pathogen Mycobacterium tuberculosis and other actinobacteria may be particularly sensitive to small molecules that perturb the activities of self-compartmentalized peptidases, which catalyze intracellular protein turnover as components of ATP-dependent...

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PMID: 24047344
DOI: 10.1021/cb400577b

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