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Targeted Protein Degradation for Infectious Diseases: from Basic Biology to Drug Discovery

15 Dec 2022

Abstract excerpt

Targeted protein degradation (TPD) is emerging as one of the most innovative strategies to tackle infectious diseases. Particularly, proteolysis-targeting chimera (PROTAC)-mediated protein degradation may offer several benefits over classical anti-infective small-molecule drugs. Because of their peculiar and catalytic mechanism of action, anti-infective PROTACs might be advantageous in terms of efficacy,...

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PMID: 37101607
DOI: 10.1021/acsbiomedchemau.2c00063

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