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Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival

1 May 2023

Abstract excerpt

The ClpC1:ClpP1P2 protease is a core component of the proteostasis system in mycobacteria. To improve the efficacy of antitubercular agents targeting the Clp protease, we characterized the mechanism of the antibiotics cyclomarin A and ecumicin. Quantitative proteomics revealed that the antibiotics cause massive proteome imbalances, including upregulation of two unannotated yet conserved stress response factors,...

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PMID: 37137307
DOI: 10.1016/j.cell.2023.04.009

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