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An immature, dedifferentiated, and lineage-deconstrained cone precursor origin of N-Myc–initiated retinoblastoma

8 Jul 2022

Abstract excerpt

Most retinoblastomas develop from maturing cone precursors in response to biallelic RB1 loss and are dependent on cone maturation-related signaling. Additionally, ∼2% lack RB1 mutations but have MYCN amplification ( MYCN A ), N-Myc protein overexpression, and more rapid and invasive growth, yet the MYCN A retinoblastoma cell of origin and basis for its responses to deregulated N-Myc are unknown. Here, using...

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PMID: 35867756
DOI: 10.1073/pnas.2200721119

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