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Article

Heterogeneity in retinoblastoma: a tale of molecules and models

9 Nov 2017

Abstract excerpt

Retinoblastoma, an intraocular pediatric cancer, develops in the embryonic retina following biallelic loss of RB1. However, there is a wide range of genetic and epigenetic changes that can affect RB1 resulting in different clinical outcomes. In addition, other transformations, such as MYCN amplification, generate particularly aggressive tumors, which may or may not be RB1 independent. Recognizing the cellular...

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PMID: 29124525
DOI: 10.1186/s40169-017-0173-2

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