Loss of photoreceptorness and gain of genomic alterations in retinoblastoma reveal tumor progression

doi:10.1016/j.ebiom.2015.06.022

Article

Loss of photoreceptorness and gain of genomic alterations in retinoblastoma reveal tumor progression

1 Jul 2015

Abstract excerpt

BACKGROUND: Retinoblastoma is a pediatric eye cancer associated with RB1 loss or MYCN amplification (RB1 (+/+) MYCN(A) ). There are controversies concerning the existence of molecular subtypes within RB1(-/-) retinoblastoma. To test whether these molecular subtypes exist, we performed molecular profiling. METHODS: Genome-wide mRNA expression profiling was performed on 76 primary human retinoblastomas. Expression...

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