Developmental stage-specific proliferation and retinoblastoma genesis in RB-deficient human but not mouse cone precursors

Abstract excerpt

Significance Retinoblastoma is a childhood tumor that forms in response to mutations in the RB1 gene and loss of functional RB protein. Prior studies suggested that retinoblastomas arise from cone photoreceptor precursors, whereas mouse models yield tumors deriving from other retinal cell types and lacking human retinoblastoma features. We show that in cultured human retinae, retinoblastomas initiate from...

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