Article

Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features

2023-03-01

Abstract excerpt

Human cone photoreceptors differ from rods and serve as the retinoblastoma cell-of-origin, yet the developmental basis for their distinct behaviors is poorly understood. Here, we used deep full-length single-cell RNA-sequencing (scRNA-seq) to distinguish post-mitotic cone and rod developmental states and identify cone-specific features that contribute to retinoblastomagenesis. The analyses revealed nascent, immedi...

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Literature Corpus work: ac5dd476-40f2-52f3-9aae-a3aacc4bb0a2
DOI: 10.1101/2023.02.28.530247

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