Article

Longitudinal analysis of retinal cell state transitions in <i>RB1</i> -deficient retinal organoids reveals the nascent cone precursors are the earliest cell-origin of human retinoblastoma

2025-03-17

Abstract excerpt

All cancers develop from malignant transformation of normal cells, while it is challenging to identify these “cells-of-origin” since it is impossible to witness the dynamic changes in human cancers. Retinoblastoma (Rb), an intraocular malignant cancer, is a typical model for study the molecular and cellular mechanisms of cancers. Although the maturing cone precursors (CPs) are proposed as the cellular origin of hu...

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Literature Corpus work: 67e7d613-2f54-56ce-a4b7-911ab098dd7f
DOI: 10.1101/2025.03.13.642537

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