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Identification and design of vinyl sulfone inhibitors against Cryptopain-1 – a cysteine protease from cryptosporidiosis-causing <i>Cryptosporidium parvum</i>

2018-05-29

Abstract excerpt

Cryptosporidiosis, a disease marked by diarrhea in adults and stunted growth in children, is associated with the unicellular protozoan pathogen Cryptosporidium; often the species parvum . Cryptopain-1, a cysteine protease characterized in the genome of Cryptosporidium parvum , had been earlier shown to be inhibited by a vinyl sulfone compound called K11777 (or K-777). Cysteine proteases have long been establish...

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Literature Corpus work
a9633d90-1ece-572a-a90b-b9a8b226e6e5
DOI
10.1101/332965
Open publication

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