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Article

Crystal Structure of Inhibitor-Bound GII.4 Sydney 2012 Norovirus 3C-Like Protease.

Viruses - 31 Oct 2023

Eruera Alice-Roza, McSweeney Alice M, McKenzie-Goldsmith Geena M, Opel-Reading Helen K, Thomas Simone X, Campbell Ashley C, Stubbing Louise, Siow Andrew, Hubert Jonathan G, Brimble Margaret A, Ward Vernon K, Krause Kurt L

Abstract excerpt

Norovirus is the leading cause of viral gastroenteritis worldwide, and there are no approved vaccines or therapeutic treatments for chronic or severe norovirus infections. The structural characterisation of the norovirus protease and drug development has predominantly focused upon GI.1 noroviruses, despite most global outbreaks being caused by GII.4 noroviruses. Here, we determined the crystal structures of the...

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Identifiers

PMID: 38005879
DOI: 10.3390/v15112202
PMCID: PMC10674469

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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