Article

Conformational flexibility is a critical factor in designing broad-spectrum human norovirus protease inhibitors

2024-09-19

Abstract excerpt

<h4>ABSTRACT</h4> Human norovirus (HuNoV) infection is a global health and economic burden. Currently, there are no licensed HuNoV vaccines or antiviral drugs available. The protease encoded by the HuNoV genome plays a critical role in virus replication by cleaving the polyprotein and is, therefore, an excellent target for developing small molecule inhibitors. While rupintrivir, a potent small-molecule inhibitor...

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Literature Corpus work: 626b2d82-75ac-5af7-affc-e90cc496fe21
DOI: 10.1101/2024.09.16.613336

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