Article
A Novel Class of Norovirus Inhibitors Targeting the Viral Protease with Potent Antiviral Activity In Vitro and In Vivo.
Viruses - 16 Sept 2021
Van Dycke Jana, Dai Wenhao, Stylianidou Zoe, Li Jian, Cuvry Arno, Roux Emma, Li Bingqian, Rymenants Jasper, Bervoets Lindsey, de Witte Peter, Liu Hong, Neyts Johan, Rocha-Pereira Joana
Abstract excerpt
Human noroviruses (HuNoVs) are the most common cause of viral gastroenteritis resulting annually in ~219,000 deaths and a societal cost of ~USD 60 billion, and no antivirals or vaccines are available. Here, we assess the anti-norovirus activity of new peptidomimetic aldehydes related to the protease inhibitor rupintrivir. The early hit compound 4 inhibited the replication of murine norovirus (MNV) and the HuNoV...
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