Back to search

Article

Computational drug repurposing identified Artemisinin and Mebendazole as potential inhibitors of virulence-associated proteins SKSR and essential kinases CpCDPK1 of <i>Cryptosporidium parvum</i>

2026-05-19

Abstract excerpt

Cryptosporidium parvum is a protozoan parasite responsible for cryptosporidiosis, significantly threatening immunocompromised individuals, particularly HIV/AIDS patients, by causing severe diarrhea and potential mortality. Current treatments are largely ineffective, prompting investigations into new therapeutic options. This study evaluated two antiparasitic drugs: Mebendazole, used for helminth infections, and Ar...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
645436a2-bf6a-5369-85b5-bee213df9b76
DOI
10.64898/2026.05.17.725751
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Computational drug repurposing identified Artemisinin and Mebendazole as potential inhibitors of virulence-associated proteins SKSR and essential kinases CpCDPK1 of <i>Cryptosporidium parvum</i>DOI 10.64898/2026.05.17.725751
Computational studies of drug repurposing targeting P-glycoprotein mediated multidrug-resistance phenotypes in agents of neglected tropical diseasesSemantic proximity
The Cryptosporidium parvum KinomeSemantic proximity
Identification and design of vinyl sulfone inhibitors against Cryptopain-1 – a cysteine protease from cryptosporidiosis-causing <i>Cryptosporidium parvum</i>Semantic proximity
Mode of action studies confirm on-target engagement of lysyl-tRNA synthetase inhibitor and lead to new selection marker for CryptosporidiumSemantic proximity
Evaluation of the basic functions of six calcium-dependent protein kinases in Toxoplasma gondii using CRISPR-Cas9 system.Semantic proximity
<i>In silico</i> Repositioning of Approved Drugs Against <i>Schistosoma mansoni</i> Energy Metabolism TargetsSemantic proximity
Genomic landscape of the emerging XDR Salmonella Typhi for mining druggable targets clpP, hisH, folP and gpmI and screening of novel TCM inhibitors, molecular docking and simulation analysesSemantic proximity
Identifying host regulators and inhibitors of liver stage malaria infection using kinase activity profilesSemantic proximity
Molecular scaffold recognition of drug molecules against essential genes of Leishmania donovani using biocomputing approachSemantic proximity
Whole-genome and mitogenome based in silico analysis of select <i>Plasmodium</i> and identification of a novel drug molecule against the malaria parasiteSemantic proximity
Homology Modeling and Docking Study of Shewanella Like Protein Phosphatase Involved in Development of Ookinetes in PlasmodiumSemantic proximity
DRUG DISCOVERY AND DEVELOPMENT FOR NEGLECTED TROPICAL DISEASESSemantic proximity
Select a neighboring publication to make it the new centre.