Article

Human Hepatocyte Nuclear Factors (HNF1 and LXRb) Regulates CYP7A1 in HIV-Infected Black South African Women with Gallstone Disease: A Preliminary Study

2021-12-13

Abstract excerpt

<h4>Background: </h4> Female sex, high estrogen levels, aging, obesity and dyslipidemia are some of the risk factors associated with gallstone formation. HIV infected patients on combination antiretroviral therapy (cART) are more prone to hypercholesterolemia. Bile acid synthesis is initiated by cholesterol 7-alpha hydroxylase (CYP7A1) and regulated by hepatocyte nuclear factors (HNF1α, HNF4α and LXRb). <h4>Aim: <...

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Literature Corpus work: a960590b-0706-561a-a52c-7668a5780096
DOI: 10.21203/rs.3.rs-1068949/v1

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