Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Decreased expression of cholesterol 7alpha-hydroxylase and altered bile acid metabolism in Apobec-1-/- mice lead to increased gallstone susceptibility.

The Journal of biological chemistry - 19 Jun 2009

Xie Yan, Blanc Valerie, Kerr Thomas A, Kennedy Susan, Luo Jianyang, Newberry Elizabeth P, Davidson Nicholas O

Abstract excerpt

Quantitative trait mapping in mice identified a susceptibility locus for gallstones (Lith6) spanning the Apobec-1 locus, the structural gene encoding the RNA-specific cytidine deaminase responsible for production of apolipoprotein B48 in mammalian small intestine and rodent liver. This observation prompted us to compare dietary gallstone susceptibility in Apobec-1(-/-) mice and congenic C57BL/6 wild type...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to APOBEC-1 Deaminase
Share to Bile Acids and Salts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholesterol 7-alpha-Hydroxylase

Share to Cytidine Deaminase

Share to Gallstones

Share to Hepatocytes

Share to Mice, Congenic

Share to RNA Processing, Post-Transcriptional

Source

Open in PubMed Open full text

Identifiers

PMID: 19386592
DOI: 10.1074/jbc.M109.010173
PMCID: PMC2719322

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Decreased expression of cholesterol 7alpha-hydroxylase and altered bile acid metabolism in Apobec-1-/- mice lead to increased gallstone susceptibility.PMID 19386592Read ↗

FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice.Semantic proximity Read ↗

Mouse models of gallstone disease.Semantic proximity Read ↗

Mechanisms of disease: the genetic epidemiology of gallbladder stones.Semantic proximity Read ↗

Investigation of the Lith6 candidate genes APOBEC1 and PPARG in human gallstone disease.Semantic proximity Read ↗

[Molecular genetics of cholesterol cholelithiasis: identification of human and murine gallstone genes].Semantic proximity Read ↗

Variation of the gene encoding the nuclear bile salt receptor FXR and gallstone susceptibility in mice and humans.Semantic proximity Read ↗

Biliary cholesterol hypersecretion in gallstone-susceptible mice is associated with hepatic up-regulation of the high-density lipoprotein receptor SRBI.Semantic proximity Read ↗

Complex genetic control of HDL levels in mice in response to an atherogenic diet. Coordinate regulation of HDL levels and bile acid metabolism.Semantic proximity Read ↗

Risk modification of colorectal adenoma by CYP7A1 polymorphisms and the role of bile acid metabolism in carcinogenesis.Semantic proximity Read ↗

Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype.Semantic proximity Read ↗

The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism.Semantic proximity Read ↗

New quantitative trait loci that contribute to cholesterol gallstone formation detected in an intercross of CAST/Ei and 129S1/SvImJ inbred mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.