Article

Dysregulation of Sterol Regulatory Element-Binding Protein 2 Gene in HIV Treatment-Experienced Individuals

2019-08-21

Abstract excerpt

We investigated the effects of antiretroviral therapy (ART) on cholesterol biosynthesis in a case-control study. mRNA and protein expressions of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and ATP binding cassette transporter A1 (ABCA1) were significantly upregulated in cases (HIV+) compared to controls (HIV-). We observed dysregulation between sterol regulatory element-binding protein 2 (SREBP-2, sens...

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Literature Corpus work: 6bc8bdd6-69e5-54a0-85b3-10af60529f43
DOI: 10.1101/742486

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