Article

<i>In vivo</i> AAV9-SB-CRISPR screen identifies fatty acid elongase ELOVL5 as a pro-resolving mediator in lung inflammation

2025-06-16

Abstract excerpt

Timely resolution of inflammation is essential to prevent tissue damage and maintain homeostasis. Immunometabolism is critical for innate immunity and inflammation. However, how metabolic enzymes and metabolites contribute to inflammatory resolution remains largely unknown. To identify the key metabolic mediators of inflammation resolution, we generated an AAV9-Sleeping Beauty CRISPR library comprising 17090 sgRNA...

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Literature Corpus work: 8a73b767-ff4d-5149-a5df-f01f578fd9f3
DOI: 10.1101/2025.06.11.659216

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