Article
The metabolic response to a high-fat diet reveals obesity-prone and -resistant phenotypes in mice with distinct mRNA-seq transcriptome profiles.
International journal of obesity (2005) - 1 Sept 2016
Choi J-Y, McGregor R A, Kwon E-Y, Kim Y J, Han Y, Park J H Y, Lee K W, Kim S-J, Kim J, Yun J W, Choi M-S
Abstract excerpt
OBJECTIVES: The aim of this study was to explore the phenotypic differences underpinning obesity susceptibility or resistance based on the metabolic and transcriptional profiling of C57BL/6J mice fed a high-fat diet (HFD). METHODS: The mice were fed either a normal diet or HFD for 12 weeks. After 6 weeks, the mice on HFD were classified as either obesity-prone (OP) or obesity-resistant (OR) depending on the body...
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