Article
Whole genome survey of coding SNPs reveals a reproducible pathway determinant of Parkinson disease.
Human mutation - 1 Feb 2009
Srinivasan Balaji S, Doostzadeh Jaleh, Absalan Farnaz, Mohandessi Sharareh, Jalili Roxana, Bigdeli Saharnaz, Wang Justin, Mahadevan Jaydev, Lee Caroline L G, Davis Ronald W, William Langston J, Ronaghi Mostafa
Abstract excerpt
It is quickly becoming apparent that situating human variation in a pathway context is crucial to understanding its phenotypic significance. Toward this end, we have developed a general method for finding pathways associated with traits that control for pathway size. We have applied this method to a new whole genome survey of coding SNP variation in 187 patients afflicted with Parkinson disease (PD) and 187...
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