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Article

Mapping the Pathways of Resistance to Targeted Therapies

21 Sept 2015

Abstract excerpt

Resistance substantially limits the depth and duration of clinical responses to targeted anticancer therapies. Through the use of complementary experimental approaches, investigators have revealed that cancer cells can achieve resistance through adaptation or selection driven by specific genetic, epigenetic, or microenvironmental alterations. Ultimately, these diverse alterations often lead to the activation of...

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Identifiers

PMID: 26392071
DOI: 10.1158/0008-5472.can-15-1248

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