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Article

Epicardial Contributions to Fibro-Inflammatory Signaling in a Pkp2-Deficient Arrhythmogenic Cardiomyopathy Model.

Circulation. Heart failure - 1 Jul 2026

Han Daniel D, Brooks Alan C, Baker Cameron D, Dirkx Ronald A, Mickelsen Deanne M, Fisler Benjamin, Phadke Kavya, Ashton John M, Delmar Mario, Small Eric M

Abstract excerpt

BACKGROUND: Arrhythmogenic cardiomyopathy (ACM) is an inherited disease that is characterized by lethal ventricular arrhythmias stemming from myocyte dysfunction. ACM is associated with considerable subepicardial fibrosis and inflammation with right ventricle predominance. Most cases of gene-positive ACM are caused by a desmosome protein mutation, with plakophilin-2 (Pkp2) mutations being the most common. We...

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Share to Arrhythmogenic Right Ventricular Dysplasia
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42246055
DOI: 10.1161/CIRCHEARTFAILURE.125.013966
PMCID: PMC13245365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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