Article
Cardiomyocyte ageing and cardioprotection: consensus document from the ESC working groups cell biology of the heart and myocardial function.
Cardiovascular research - 1 Sept 2020
Ruiz-Meana Marisol, Bou-Teen Diana, Ferdinandy Péter, Gyongyosi Mariann, Pesce Maurizio, Perrino Cinzia, Schulz Rainer, Sluijter Joost P G, Tocchetti Carlo G, Thum Thomas, Madonna Rosalinda
Abstract excerpt
Advanced age is a major predisposing risk factor for the incidence of coronary syndromes and comorbid conditions which impact the heart response to cardioprotective interventions. Advanced age also significantly increases the risk of developing post-ischaemic adverse remodelling and heart failure after ischaemia/reperfusion (IR) injury. Some of the signalling pathways become defective or attenuated during ageing,...
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