Article

Mapping the unicellular transcriptome of the ascending thoracic aorta to changes in mechanosensing and mechanoadaptation during aging

2022-07-22

Abstract excerpt

<h4>ABSTRACT</h4> Aortic stiffening is an inevitable manifestation of chronological aging, yet the mechano-molecular programs that orchestrate region- and layer-specific adaptations along the length and through the wall of the aorta are incompletely defined. Here, we show that the decline in passive cyclic distensibility is more pronounced in the ascending thoracic (ATA) compared to distal segments of the aorta a...

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Literature Corpus work: 50b01d61-c655-57f7-9c8a-c7333d4d0406
DOI: 10.1101/2022.07.21.501037

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Mapping the unicellular transcriptome of the ascending thoracic aorta to changes in mechanosensing and mechanoadaptation during agingDOI 10.1101/2022.07.21.501037Read

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