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Article

TP53 mutations increase radioresistance in rhabdomyosarcoma and Ewing sarcoma.

British journal of cancer - 1 Aug 2021

Casey Dana L, Pitter Kenneth L, Wexler Leonard H, Slotkin Emily K, Gupta Gaorav P, Wolden Suzanne L

Abstract excerpt

BACKGROUND: p53 plays a key role in the DNA repair process and response to ionising radiation. We sought to determine the clinical phenotype of TP53 mutations and p53 pathway alterations in patients with rhabdomyosarcoma (RMS) and Ewing sarcoma (ES) treated with radiation. METHODS: Of patients with available genomic sequencing, we identified 109 patients with RMS and ES treated to a total of 286 radiation sites....

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Identifiers

PMID: 34017087
DOI: 10.1038/s41416-021-01438-2
PMCID: PMC8368014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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